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Exocytosis (/ ˌ ɛ k s oʊ s aɪ ˈ t oʊ s ɪ s / [1] [2]) is a form of active transport and bulk transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell (exo-+ cytosis). As an active transport mechanism, exocytosis requires the use of energy to transport material.
In phagocytosis, involving the destruction of pathogens, the pathogens are surrounded and then engulfed through endocytosis. The vacuole then forms and closes around the pathogens. In exocytosis, the lysosome and vacuole fuse together which allows enzymes to destroy pathogens. Debris from the pathogens is then released from the cell.
Exocytosis (L) and Endocytosis (R) Exocytosis is when a cell directs the contents of secretory vesicles out of the cell membrane. The vesicles fuse with the cell membrane and their content, usually protein, is released out of the cell. There are two types of exocytosis: Constitutive secretion and Regulated secretion.
Anything left in the food vacuole by the time it reaches the cytoproct is discharged by exocytosis. Most ciliates also have one or more prominent contractile vacuoles , which collect water and expel it from the cell to maintain osmotic pressure , or in some function to maintain ionic balance.
Eventually, there is vesicle fusion with the cell membrane at porosomes, by a process called exocytosis, dumping its contents out of the cell's environment. [2] Strict biochemical control is maintained over this sequence by usage of a pH gradient: the pH of the cytosol is 7.4, the ER's pH is 7.0, and the cis-golgi has a pH of 6.5.
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The 2013 Nobel Prize in Physiology or Medicine was shared by James Rothman, Randy Schekman and Thomas Südhof for their roles in elucidating (building upon earlier research, some of it by their mentors) the makeup and function of cell vesicles, especially in yeasts and in humans, including information on each vesicle's parts and how they are assembled.
Kiss-and-run fusion is a type of synaptic vesicle release where the vesicle opens and closes transiently. In this form of exocytosis, the vesicle docks and transiently fuses at the presynaptic membrane and releases its neurotransmitters across the synapse, after which the vesicle can then be reused.