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Cannabis use is also suspected to contribute to a hyperdopaminergic state that may contribute to schizophrenia. [13] [133] Compounds found in cannabis, such as THC, have been shown to increase the activity of dopamine pathways in the brain, [134] suggesting that cannabis may exacerbate symptoms of psychosis in schizophrenia.
The causes of schizophrenia that underlie the development of schizophrenia, a psychiatric disorder, are complex and not clearly understood.A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link between altered brain function and the symptoms and development of schizophrenia.
Schizophrenia is a mental disorder characterized by significant alterations in perception, thoughts, mood, and behavior. [34] Symptoms are described in terms of positive, negative, and cognitive symptoms. [3] [35] The positive symptoms of schizophrenia are the same for any psychosis and are sometimes referred to as psychotic symptoms. These may ...
Risk factors for mental illness include psychological trauma, adverse childhood experiences, genetic predisposition, and personality traits. [7] [8] Correlations between mental disorders and substance use are also found to have a two way relationship, in that substance use can lead to the development of mental disorders and having mental disorders can lead to substance use/abuse.
Various neurotrophic factors dysregulate in schizophrenia and other mental illnesses, namely BDNF; expression of which is lowered in schizophrenia as well as in major depression and bipolar disorder. [ 9 ] [ 10 ] BDNF regulates in an AMPA-dependent mechanism [ 11 ] - AMPA and BDNF alike are critical mediators of growth cone survival. [ 12 ]
The core symptoms of schizophrenia can be classified into three broad categories. These symptoms are often used to build and study animal models of schizophrenia in the field of epigenetics. [1] Positive symptoms are considered limbic system aberrations, while negative and cognitive symptoms are thought of as frontal lobe abnormalities. [4]
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