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Giant cell arteritis (GCA), also called temporal arteritis, is an inflammatory autoimmune disease of large blood vessels. [ 4 ] [ 7 ] Symptoms may include headache , pain over the temples, flu-like symptoms , double vision , and difficulty opening the mouth. [ 3 ]
Arteritis is a vascular disorder characterized by inflammation of the walls of arteries, [1] usually as a result of infection or autoimmune responses. Arteritis, a complex disorder, is still not entirely understood. [2] Arteritis may be distinguished by its different types, based on the organ systems affected by the disease. [2]
Classic microscopic features of GPA include inflammation of blood vessels associated with poorly formed granulomas, necrosis, and many giant cells. [19] Bacterial colonization with Staphylococcus aureus has been hypothesized as an initiating factor of the autoimmunity seen in people with GPA. [ 8 ]
The halo sign of temporal arteritis should not be confused with Deuel's halo sign, which is a sign of fetal death. [ 3 ] The halo sign is also understood as a region of ground-glass attenuation surrounding a pulmonary nodule on an X-ray computed tomography (CT scan) of the chest.
Giant cell arteritis (GCA) is the most common type of systemic vasculitis in adults. Polymyalgia rheumatica (PMR), headache, jaw claudication , and visual symptoms are the classic manifestations; however, 40% of patients present with a variety of occult manifestations.
The structure of the vasa vasorum varies with the size, function and location of the vessels. Cells need to be within a few cell-widths of a capillary to stay alive. In the largest vessels, the vasa vasorum penetrates the outer (tunica adventitia) layer and middle (tunica media) layer almost to the inner (tunica intima) layer.
AAION is due to temporal arteritis (also called giant-cell arteritis), an inflammatory disease of medium-sized blood vessels (Chapel-Hill-Conference) that occurs especially with advancing age. In contrast, NAION results from the coincidence of cardiovascular risk factors in a patient with "crowded" optic discs.
Magnetic resonance angiography (MRA) is a group of techniques based on magnetic resonance imaging (MRI) to image blood vessels. Magnetic resonance angiography is used to generate images of arteries (and less commonly veins) in order to evaluate them for stenosis (abnormal narrowing), occlusions, aneurysms (vessel wall dilatations, at risk of rupture) or other abnormalities.