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High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [ 2 ] [ 3 ] Using robotics , data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to ...
Given its ability to capture a wide array of cellular responses, the Cell Painting assay has become a powerful tool in the field of drug discovery. [9] By comparing the morphological profiles of cells treated with different compounds, researchers can identify potential drug candidates, toxicity [10] or understand the mechanism of action of existing drugs.
As above mentioned, combinatorial chemistry was a key technology enabling the efficient generation of large screening libraries for the needs of high-throughput screening. However, now, after two decades of combinatorial chemistry, it has been pointed out that despite the increased efficiency in chemical synthesis, no increase in lead or drug ...
Compound management in the field of drug discovery refers to the systematic collection, storage, retrieval, and quality control of small molecule chemical compounds used in high-throughput screening and other research activities to identify hits that can be developed into candidate drugs.
Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds.
In high-throughput screening (HTS), one of the major goals is to select compounds (including small molecules, siRNAs, shRNA, genes, et al.) with a desired size of inhibition or activation effects. A compound with a desired size of effects in an HTS screen is called a hit. The process of selecting hits is called hit selection. [citation needed]
High throughput screening of compounds and targets in drug discovery (Labeled Alpha Screen on most instruments) [12] Bead-based epitope assay [13] Cellular Uptake of nanoparticles [14] While "plate reader" usually refers to the devices described above, many variations are available. Some examples of other devices working with the microplate ...
Chemogenomics Staubli robot retrieves assay plates from incubators. Chemogenomics, or chemical genomics, is the systematic screening of targeted chemical libraries of small molecules against individual drug target families (e.g., GPCRs, nuclear receptors, kinases, proteases, etc.) with the ultimate goal of identification of novel drugs and drug targets. [1]