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[7] [16] [17] [18] They are indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations in dogs and puppies (8 weeks of age and older, weighing 4 pounds (~1.8 kilograms) of body weight or greater) for one month.
To provide context for the dosing and toxicity ranges, the LD 50 of ivermectin in mice is 25 mg/kg (oral), and 80 mg/kg in dogs, corresponding to an approximated human-equivalent dose LD 50 range of 2.02–43.24 mg/kg, [65] which is far more than its FDA-approved usage (a single dose of 0.150–0.200 mg/kg to be used for specific parasitic ...
The lethal dose for 50% of dogs is 100 – 200 mg per kilogram (kg) of body weight, yet some dogs will exhibit signs of toxicosis after ingesting as little as 20 mg per kg. [38] In case of accidental intake of chocolate, especially involving a smaller dog, contact a veterinarian or animal poison control immediately; it is commonly recommended ...
The maximum tolerable dose (MTD) information is necessary to be able to design such groups and therefore dose-ranging studies are usually designed after the availability of MTD information. [1] The main goal of a dose-ranging study is to estimate the response vs. dose given, so as to analyze the efficacy and safety of the drug.
The primary antidote to brodifacoum poisoning is immediate administration of vitamin K 1 (dosage for humans: initially slow intravenous injections of 10–25 mg repeated at 3–6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the ...
Coren's book presents a ranked list of breed intelligence, based on a survey of 208 dog obedience judges across North America. [10] When it was first published there was much media attention and commentary in terms of both pros [11] and cons. [12] Over the years, Coren's ranking of breeds and methodology have come to be accepted as a valid description of the differences among dog breeds in ...