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G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
G6PD deficient red cells in combination with high levels of oxidants causes a cross-linking of sulfhydryl groups on globin chains which causes a denaturing and formation of Heinz body precipitates. [8] Heinz bodies can also be found in chronic liver disease. [9] Alpha-thalassemia. Normal adult hemoglobin is composed of two alpha and two beta ...
Negara Daha was a Hindu kingdom successor of Negara Dipa that appears in the Hikayat Banjar. It was located in what is now the Regency of Hulu Sungai Selatan , Province of South Kalimantan , Republic of Indonesia .
The National Principles (Malay: Rukun Negara; Jawi: روکون نݢارا ) is the Malaysian declaration of national philosophy instituted by royal proclamation on Merdeka Day, 1970, in reaction to the 13 May race riots, which occurred in 1969. [1]
A failed state is a state that has lost its ability to fulfill fundamental security and development functions, lacking effective control over its territory and borders. . Common characteristics of a failed state include a government incapable of tax collection, law enforcement, security assurance, territorial control, political or civil office staffing, and infrastructure maintenan
Pancasila (Indonesian: [pantʃaˈsila] ⓘ) is the official, foundational philosophical theory of Indonesia.The name is made from two words originally derived from Sanskrit: "pañca" ("five") and "śīla" ("principles", "precepts").