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Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. [1] The effect is most studied with grapefruit and grapefruit juice, [1] but similar effects have been observed with certain other citrus fruits.
"According to the FDA, Seville oranges and tangelos may interact the same way that grapefruit does on certain medications," says Gans. It's also a good idea to read the paperwork that comes with ...
In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
In the case of grapefruit and Cialis, this liquid or the fruit itself produces an unwanted effect — known as a “drug interaction.” Cialis also interacts with drugs like alpha blockers and ...
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Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
[8] [11] Phytochemicals in grapefruit seeds, particularly furanocoumarins and flavonoids, may cause adverse effects on health resulting from grapefruit–drug interactions that influence the intended therapeutic effects of some 85 prescription drugs.