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Grapefruit juice may potentially reduce the effectiveness of tamoxifen. [84] Trazodone (Desyrel): Little or no interaction with grapefruit juice. [85] Verapamil (Calan SR, Covera HS, Isoptin SR, Verelan): atrioventricular conduction disorders. [61] Warfarin (coumadin) [86] Zolpidem (Ambien): Little or no interaction with grapefruit juice [85]
"The best way to monitor for a grapefruit medication interaction is to look out for the side effects of the drug," says Peterson "They should be listed in your paperwork from your prescription and ...
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs.
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Grapefruit juice can be a problem too. If you want to take Cialis at night, you may have to stop eating grapefruit in the morning. Our guide to Cialis and grapefruit interactions explains more ...
Simvastatin has important interactions with grapefruit juice and other drugs, ... diltiazem, amiodarone, amlodipine, and ranolazine. ...
Unlike orange juice, grapefruit juice can impact how Cialis is metabolized in your body, leading to increased levels of the medication in your system. That can be dangerous for a variety of reasons.