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It carries the antigenic determinants of the Duffy blood group system which consist of four codominant alleles—FY*A and FY*B—coding for the Fy-a and Fy-b antigens respectively, FY*X and FY*Fy, five phenotypes (Fy-a, Fy-b, Fy-o, Fy-x and Fy-y) and five antigens. Fy-x is a form of Fy-b where the Fy-b gene is poorly expressed.
[jargon] [52] In widely cited in vitro and in vivo studies, Miller et al. reported that the Duffy blood group is the receptor for P. vivax and that the absence of the Duffy blood group on red cells is the resistance factor to P. vivax in persons of African descent. [5]
The Cobas malaria test, made by Roche, can detect RNA and DNA from the parasite that causes malaria in donor blood, organs and tissue. Malaria transmission through a blood transfusion is not ...
A WHO report on 8 December 2024 reported ongoing laboratory tests to determine the cause of the disease, but noted that it is also possible more than one disease is involved. Acute pneumonia , influenza , COVID-19 , measles , hemolytic uremic syndrome from E. coli , and malaria were being considered as potential causes, with malnutrition as a ...
The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...
Blackwater fever is caused by heavy parasitization of red blood cells with Plasmodium falciparum. However, there have been other cases attributed to Plasmodium vivax, [1] Plasmodium malariae, [2] Plasmodium knowlesi. [3] Blackwater fever is a serious complication of malaria, but cerebral malaria has a higher mortality rate.
Malaria is the deadliest among infectious diseases, accounting for approximately 429,000 human deaths in 2015 as of the latest estimate by the World Health Organization. [2] In humans, malaria can be caused by five Plasmodium parasites, namely P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. [3]
In molecular biology, Duffy binding proteins are found in Plasmodium. Plasmodium vivax and Plasmodium knowlesi merozoites invade Homo sapiens erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa. [1] [2]