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[58] [59] 5E1, a monoclonal antibody against Shh, has been shown to inhibit medulloblastoma growth in mouse models. [60] 5E1 also restricts the proliferation of pancreatic cancer cells in mice. [61] While shown to be effective in the lab, both these Shh inhibitors are yet to make their way to human trials.
The SHH gene is a member of the hedgehog gene family with five variations of DNA sequence alterations or splice variants. [37] SHH is located on chromosome seven and initiates the production of Sonic Hedgehog protein. [37] This protein sends short- and long-range signals to embryonic tissues to regulate development. [38]
Holoprosencephaly, the failure of the embryonic prosencephalon to divide to form cerebral hemispheres, occurs with a frequency of about 1 in 8,000 live births and about 1 in 200 spontaneous abortions in humans and is commonly linked to mutations in genes involved in the hedgehog pathway, including SHH and PTCH. [37]
319757 Ensembl ENSG00000128602 ENSMUSG00000001761 UniProt Q99835 P56726 RefSeq (mRNA) NM_005631 NM_176996 RefSeq (protein) NP_005622 NP_795970 Location (UCSC) Chr 7: 129.19 – 129.21 Mb Chr 6: 29.74 – 29.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Smoothened is a protein that in humans is encoded by the SMO gene. Smoothened is a Class Frizzled (Class F) G protein-coupled ...
Silmitasertib is in clinical trials for use as an adjunct to chemotherapy in the treatment of cholangiocarcinoma (bile duct cancer), [1] is in phase I and II clinical trials for the treatment of recurrent Sonic Hedgehog (SHH) medulloblastoma, [2] [3] and in preclinical development for other cancers, including hematological and lymphoid ...
Although expression of Shh pathway proteins has not been reported to oscillate in the pre-somitic mesoderm, they are expressed within the pre-somitic mesoderm during somitogenesis. When the notochord is ablated during somitogenesis in the chick embryo, the proper number of somites forms, but the segmentation clock is delayed for the posterior ...
Shh is recognised as a limb-specific enhancer. [41] Shh is both sufficient and necessary to create the ZPA and specify the craniocaudal pattern in the distal limb (Shh is not necessary for the polarity of the stylopod). Shh is turned on in the posterior through the early expression of Hoxd genes, the expression of Hoxb8, and the expression dHAND.
2735 14632 Ensembl ENSG00000111087 ENSMUSG00000025407 UniProt P08151 P47806 RefSeq (mRNA) NM_001160045 NM_001167609 NM_005269 NM_010296 RefSeq (protein) NP_001153517 NP_001161081 NP_005260 NP_034426 Location (UCSC) Chr 12: 57.46 – 57.47 Mb Chr 10: 127.17 – 127.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Zinc finger protein GLI1 also known as glioma-associated oncogene is a ...