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16846 Ensembl ENSG00000174697 ENSMUSG00000059201 UniProt P41159 P41160 RefSeq (mRNA) NM_000230 NM_008493 RefSeq (protein) NP_000221 NP_032519 Location (UCSC) Chr 7: 128.24 – 128.26 Mb Chr 6: 29.06 – 29.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein family Leptin Structure of the obese protein leptin-E100 Identifiers Symbol Leptin Pfam PF02024 Pfam clan CL0053 InterPro ...
Leptin, a hormone secreted exclusively by adipose cells in response to an increase in body fat mass, is an important component in the regulation of long term hunger and food intake. Leptin serves as the brain's indicator of the body's total energy stores. When leptin levels rise in the bloodstream they bind to receptors in ARC. The functions of ...
Leptin receptor, also known as LEP-R or OB-R, is a type I cytokine receptor, [5] a protein that in humans is encoded by the LEPR gene. [ 6 ] [ 7 ] LEP-R functions as a receptor for the fat cell-specific hormone leptin .
Douglas L. Coleman (October 6, 1931 - April 16, 2014) was a scientist and professor emeritus at the Jackson Laboratory, in Bar Harbor, Maine.His work predicted that there exists a hormone that can cause mice to feel full, and that a mutation in the gene encoding this hormone can lead to obesity. [3]
In a study with 3000 patients, it was found that men and women who sleep less than 5 hours have elevated body mass index (BMI). In another study that followed about 70.000 women for 16 years, there was a significant increase in body weight in those who slept 5 hours or less compared to those who slept 7–8 hours. [1] [2] [8]
The first adipokine to be discovered was leptin in 1994. [2] Since that time, hundreds of adipokines have been discovered. [3] Members include: Leptin; Adiponectin; Apelin [4] chemerin [5] interleukin-6 (IL-6) [6] monocyte chemotactic protein-1 (MCP-1) [7] plasminogen activator inhibitor-1 (PAI-1) retinol binding protein 4 (RBP4) tumor necrosis ...
109648 Ensembl ENSG00000122585 ENSMUSG00000029819 UniProt P01303 P57774 RefSeq (mRNA) NM_000905 NM_023456 RefSeq (protein) NP_000896 NP_075945 Location (UCSC) Chr 7: 24.28 – 24.29 Mb Chr 6: 49.8 – 49.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Pharmaceutical compound Neuropeptide Y Identifiers CAS Number 82785-45-3 N ChemSpider none UNII BY7U39XXK0 ChEMBL ChEMBL267633 N ...
Nesfatin-1 is a polypeptide encoded in the N-terminal region of the protein precursor, Nucleobindin-2 . Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues. [4] Nesfatin-1 is expressed in the hypothalamus, in other areas of the brain, and in pancreatic islets, gastric endocrine cells and adipocytes.