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The AP-1 transcription factor also has been shown to be involved in breast cancer cell growth through multiple mechanisms, including regulation of cyclin D1, E2F factors and their target genes. c-Jun, which is one of the AP-1 subunits, regulates the growth of breast cancer cells.
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
Three groups of transcription factors are known to be important in human cancer: (1) the NF-kappaB and AP-1 families, (2) ... or about their target genes. Examples ...
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. [1] The AP-1 binding site, in humans, has a nucleotide sequence of ATGAGTCAT, where A corresponds to adenine , T corresponds to thymine , G corresponds to guanine , and C corresponds to cytosine .
211556 Ensembl ENSG00000138660 ENSMUSG00000074238 UniProt Q63HQ0 n/a RefSeq (mRNA) NM_001128426 NM_018569 NM_145964 NM_001346718 RefSeq (protein) NP_001121898 NP_061039 n/a Location (UCSC) Chr 4: 112.23 – 112.27 Mb Chr 3: 127.6 – 127.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex-associated regulatory protein (Gamma1-adaptin brefeldin A resistance protein) is a ...
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene. [5] [6] [7]Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors.
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1174 11769 Ensembl ENSG00000106367 ENSMUSG00000004849 UniProt P61966 P61967 RefSeq (mRNA) NM_057089 NM_001283 NM_007457 RefSeq (protein) NP_001274 NP_031483 Location (UCSC) Chr 7: 101.15 – 101.16 Mb Chr 5: 137.06 – 137.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. Function The protein ...