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[1] [3] Other forms of statin associated muscle damage usually resolve after stopping the involved statin. [1] Mild joint pain and rash may be present. [3] In people affected by SAAM, the median duration of statin therapy was 38 months before the onset of muscular symptoms. [4]
Although a 2018 meta-analysis concluded that there was preliminary evidence for oral CoQ 10 reducing statin-associated muscle symptoms, including muscle pain, muscle weakness, muscle cramps, and muscle tiredness, [42] 2015 [43] and 2024 [30] meta-analysis found that CoQ 10 had no effect on statin myopathy. [43] [30]
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Common types of myopathy due to statins include myalgia, myositis, and rhabdomyolysis. Statins induce myopathy by inhibiting protein synthesis within the muscle. [6] Statin therapy tends to not show any histopathological differences, and thus a biopsy does not reveal too much about the damage. Often, the damage is found within the mitochondria.
Other possible signs of heart problems may include: jaw pain, shoulder pain, the sensation that your bra is too tight, feeling winded as you walk, fatigue, flu-like symptoms, sweatiness, nausea ...
Cholesterol-lowering medications such as statins are recommended for both men and women with coronary artery disease. They can help reduce symptoms and prevent heart attacks and death.