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  2. Cortisol - Wikipedia

    en.wikipedia.org/wiki/Cortisol

    Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.When used as medication, it is known as hydrocortisone.. It is produced in many animals, mainly by the zona fasciculata of the adrenal cortex in an adrenal gland. [1]

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  4. Glucocorticoid - Wikipedia

    en.wikipedia.org/wiki/Glucocorticoid

    Dexamethasone is based on the cortisol structure but differs at three positions (extra double bond in the A-ring between carbons 1 and 2 and addition of a 9-α-fluoro group and a 16-α-methyl substituent). A variety of synthetic glucocorticoids, some far more potent than cortisol, have been created for therapeutic use.

  5. Adrenal gland - Wikipedia

    en.wikipedia.org/wiki/Adrenal_gland

    Cortisol reduces the capacity of osteoblasts to produce new bone tissue and decreases the absorption of calcium in the gastrointestinal tract. [ 28 ] The adrenal gland secretes a basal level of cortisol but can also produce bursts of the hormone in response to adrenocorticotropic hormone (ACTH) from the anterior pituitary .

  6. Hormone - Wikipedia

    en.wikipedia.org/wiki/Hormone

    Steroid hormones are derived from cholesterol. Examples include the sex hormones estradiol and testosterone as well as the stress hormone cortisol. [23] Steroids contain four fused rings. They are lipophilic and hence can cross membranes to bind to intracellular nuclear receptors. 4 Eicosanoids

  7. Cholesterol side-chain cleavage enzyme - Wikipedia

    en.wikipedia.org/wiki/Cholesterol_side-chain...

    Upon stimulation of a cell to make steroid, the amount of StAR available to transfer cholesterol to the inner membrane limits how fast the reaction can go (the acute phase). With prolonged (chronic) stimulation, it is thought that cholesterol supply becomes no longer an issue and that the capacity of the system to make steroid (i.e., level of ...