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Drug-induced angioedema is a known complication of the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists (ARBs), and Angiotensin-Neprilysin Inhibitor LCZ969. [ 1 ] : 120 The angioedema appears to be dose dependent as it may resolve with decreased dose.
In people with ACE inhibitor angioedema, the drug needs to be discontinued and an alternative treatment needs to be found, such as an angiotensin II receptor blocker (ARB), [17] which has a similar mechanism but does not affect bradykinin. However, this is controversial, as small studies have shown some patients with ACE inhibitor angioedema ...
Treatment of acquired angioedema is separated into two main parts. First controlling acute symptoms during angioedema attacks is crucial for preventing and lowering the risk of mortality. [ 20 ] Second, managing AAE chronically with prophylactic treatment is important to improve prognosis and quality of life. [ 20 ]
Icatibant, sold under the brand name Firazyr, is a medication for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. [5] [3] [4] It is not effective in angioedema caused by medication from the ACE inhibitor class. [6]
Angiotensin II receptor blockers are used primarily for the treatment of hypertension where the patient is intolerant of ACE inhibitor therapy primarily because of persistent and/or dry cough. [6] They do not inhibit the breakdown of bradykinin or other kinins , and are thus only rarely associated with the persistent dry cough and/or angioedema ...
Any medication can cause an allergic reaction, says Dr. Zalvan, but some medications can cause them more often, such as ACE inhibitors (a blood pressure medication).
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