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  2. Acute tryptophan depletion - Wikipedia

    en.wikipedia.org/wiki/Acute_tryptophan_depletion

    Acute tryptophan depletion (ATD) is a technique used extensively to study the effect of low serotonin in the brain. [1] This experimental approach reduces the availability of tryptophan , an amino acid which serves as the precursor to serotonin.

  3. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    This region is extremely rich in serotonin transporters and is considered as a governor for a vast network involving areas like hypothalamus and brain stem, which influences changes in appetite and sleep; the amygdala and insula, which affect the mood and anxiety; the hippocampus, which plays an important role in memory formation; and some ...

  4. Tryptophan - Wikipedia

    en.wikipedia.org/wiki/Tryptophan

    Low brain serotonin level is induced by administration of tryptophan-poor protein in a technique called acute tryptophan depletion. [68] Studies using this method have evaluated the effect of serotonin on mood and social behavior, finding that serotonin reduces aggression and increases agreeableness. [69]

  5. Monoamine neurotransmitter - Wikipedia

    en.wikipedia.org/wiki/Monoamine_neurotransmitter

    A phylogenetic tree showing how a number of monoamine receptors are related to each other. Monoamine neurotransmitter systems occur in virtually all vertebrates, where the evolvability of these systems has served to promote the adaptability of vertebrate species to different environments.

  6. Tryptophan hydroxylase - Wikipedia

    en.wikipedia.org/wiki/Tryptophan_hydroxylase

    Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase , phenylalanine hydroxylase , and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases .

  7. Median raphe nucleus - Wikipedia

    en.wikipedia.org/wiki/Median_raphe_nucleus

    The MRN is one of the few brain regions producing tryptophan hydroxylase, a rate-limiting enzyme of serotonin biosynthesis. Increased levels of tryptophan hydroxylase 2 mRNA (and, consequently, tryptophan hydroxylase) have been noted in suicidal depressed individuals as compared to non-psychiatric controls.