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Gelatinases are enzymes capable of degrading gelatin through hydrolysis, playing a major role in degradation of extracellular matrix and tissue remodeling. Gelatinases are a type of matrix metalloproteinase (MMP), a family of enzymes that depend on zinc as a cofactor and can break down parts of the extracellular matrix . [ 1 ]
Cancer cell invasion, ECM degradation, and metastasis are highly linked with the presence of invadopodia, protrusive and adhesive structures on cancer cells. Invadopodia have been shown to concentrate MMPs (including MT1-MMP , MMP-2, and MMP-9) for localized release and activation. [ 16 ]
17395 Ensembl ENSG00000100985 ENSMUSG00000017737 UniProt P14780 P41245 RefSeq (mRNA) NM_004994 NM_013599 RefSeq (protein) NP_004985 NP_038627 Location (UCSC) Chr 20: 46.01 – 46.02 Mb Chr 2: 164.78 – 164.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a ...
The gelatinases are No. 2 and No. 9. The stromelysins display a broad ability to cleave extracellular matrix proteins but are unable to cleave the triple-helical fibrillar collagens. The three canonical members of this group are No. 3, No. 10, and No. 11.
The overexpression of MMP-28 is linked to the metastasis of tumors in cancer. [13] Expression of MMP-28 can be linked to tumor diameter, depth of invasion, and stage of metastasis. In patients with positive overexpression of MMP-28, survival may be significantly less likely compared to negative expression of this protein, making it a ...
Cancer of the rectum and large intestine is on a deadly march among people as young as age 20, with diagnosed cases continuing to rise among those younger than 50 in the United States and around ...
The primary function of MMP-8 is the degradation of type I, II and III collagens. In cancer, loss of MMP-8 in the murine MMTV-PyMT breast cancer model has been associated with increased tumor growth and metastatic burden, as well as enhanced tumor vascularity and altered immune cell infiltration. [8]
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