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Response rates of over 80% are reported in HPV+ cancer and three-year progression-free survival has been reported as 75–82% and 45–57%, respectively, for HPV+ and HPV- cancer, and improving over increasing time.
People with HPV-positive oropharyngeal cancer tend to have higher survival rates. [1] [6] However, HPV is tested for by the presence of the biomarker p16, which normally increases in the presence of HPV. Some people can have elevated levels of p16 but test negative for HPV and vice versa. This is known as discordant cancer. The five-year ...
Overall rates of HPV-associated invasive cancers may be increasing. Between 1994 and 2014, there was a 2% increase in the rate of HPV-associated invasive cancers per year for both sexes in Ireland. [197] As HPV is known to be associated with anogenital warts, these are notifiable to the Health Protection Surveillance Centre (HPSC).
Despite evidence that the HPV vaccine is safe, effective and can help prevent cancer, HPV vaccination rates in the U.S. remain “suboptimal,” say experts.
Misconceptions about HPV hold back vaccination rates in males and females, which experts believe should be higher. ... There were 11.5 cases of HPV-related cancer per 100,000 vaccinated females ...
HPV-positive oropharyngeal cancer generally has a better outcome than HPV-negative disease, with a 54% better survival rate, [18] but this advantage for HPV-associated cancer applies only to oropharyngeal cancers. [19] People with oropharyngeal carcinomas are at high risk of developing a second primary head and neck cancer. [20]
The American Cancer Society’s Cancer Statistics, 2025 report found that the death rate due to cancer decreased by 34% from 1991 to 2022 in the U.S., due to declines in the four most common types ...
In a retrospective trial analysis of patients with Stage III and IV oropharyngeal cancer, HPV status was assessed and it was found that the 3-year rates of overall survival were 82.4% (95% CI, 77.2 to 87.6) in the HPV-positive subgroup and 57.1% (95% CI, 48.1 to 66.1) in the HPV-negative subgroup, and the 3-year rates of progression-free ...