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  2. Beta thalassemia - Wikipedia

    en.wikipedia.org/wiki/Beta_thalassemia

    Beta thalassemias (β thalassemias) are a group of inherited blood disorders. They are forms of thalassemia caused by reduced or absent synthesis of the beta chains of hemoglobin that result in variable outcomes ranging from severe anemia to clinically asymptomatic individuals. Global annual incidence is estimated at one in 100,000. [4]

  3. Thalassemia - Wikipedia

    en.wikipedia.org/wiki/Thalassemia

    There are two main types, alpha thalassemia and beta thalassemia. [7] The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing. [2] Diagnosis is typically by blood tests including a complete blood count, special hemoglobin tests, and genetic tests. [3]

  4. Alpha-thalassemia - Wikipedia

    en.wikipedia.org/wiki/Alpha-thalassemia

    Treatment. Blood transfusion, possible splenectomy [1][4] Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 [5] and HBA2. [6] Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. [7]

  5. Hemoglobinopathy - Wikipedia

    en.wikipedia.org/wiki/Hemoglobinopathy

    Specialty. Hematology. Hemoglobinopathy is the medical term for a group of inherited blood disorders involving the hemoglobin, the protein of red blood cells. [1] They are single-gene disorders and, in most cases, they are inherited as autosomal co-dominant traits. [2]

  6. FDA clears first CRISPR treatment for a second disease, beta ...

    www.aol.com/fda-clears-first-crispr-treatment...

    The groundbreaking treatment can now also be used to treat transfusion-dependent beta thalassemia in people 12 and older. Like sickle cell, beta thalassemia is an inherited blood disorder.

  7. Hemoglobin H disease - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_H_disease

    Hemoglobin H disease is a genetic disorder resulting in absent or impaired production of the α-globin protein, a normal component of the hemoglobin. The disease occurs when the α-globin gene expression is reduced to less than 30% of the normal expression. [2] In a healthy individual there are four copies of the gene which encode the alpha ...

  8. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    Hematology. Sickle cell trait describes a condition in which a person has one abnormal allele of the hemoglobin beta gene (is heterozygous), but does not display the severe symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous). Those who are heterozygous for the sickle cell allele produce both ...

  9. Management of thalassemia - Wikipedia

    en.wikipedia.org/wiki/Management_of_thalassemia

    Management of thalassemia. Treatment of the inherited blood disorder thalassemia depends upon the level of severity. For mild forms of the condition, advice and counseling are often all that are necessary. For more severe forms, treatment may consist in blood transfusion; chelation therapy to reverse iron overload, using drugs such as ...

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