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Synaptic plasticity rule for gradient estimation by dynamic perturbation of conductances. In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. [1] Since memories are postulated to be represented by vastly interconnected neural circuits in the ...
Synaptogenesis is the formation of synapses between neurons in the nervous system. Although it occurs throughout a healthy person's lifespan, an explosion of synapse formation occurs during early brain development, known as exuberant synaptogenesis. [ 1 ] Synaptogenesis is particularly important during an individual's critical period, during ...
Excitatory synapse. A diagram of a typical central nervous system synapse. The spheres located in the upper neuron contain neurotransmitters that fuse with the presynaptic membrane and release neurotransmitters into the synaptic cleft. These neurotransmitters bind to receptors located on the postsynaptic membrane of the lower neuron, and, in ...
Synaptic pruning. A model view of the synapse. Synaptic pruning, a phase in the development of the nervous system, is the process of synapse elimination that occurs between early childhood and the onset of puberty in many mammals, including humans. [1] Pruning starts near the time of birth and continues into the late-20s. [2]
Synaptic stabilization. Synaptic stabilization is crucial in the developing and adult nervous systems and is considered a result of the late phase of long-term potentiation (LTP). The mechanism involves strengthening and maintaining active synapses through increased expression of cytoskeletal and extracellular matrix elements and postsynaptic ...
The synaptotropic hypothesis, also called the synaptotrophic hypothesis, is a neurobiological hypothesis of neuronal growth and synapse formation. The hypothesis was first formulated by J.E. Vaughn in 1988, [1] and remains a focus of current research efforts. [2] The synaptotropic hypothesis proposes that input from a presynaptic to a ...
Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body. At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the ...
This mechanism conserves the total synaptic weight across the cell by introducing competition between synapses. Thus, normalizing a single neuron after plasticity. [10] During development, cells can be refined when some synapses are preserved and others are discarded to normalize total synaptic weight.