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The two presented their findings on the use of scopolamine during childbirth at the 1906 National Obstetrics Conference in Berlin, Germany. [8] They recorded preferred dosages and adverse side effects of scopolamine, which included slowed pulse, bradypnea, delirium, dilated pupils, flushed skin, and thirst. [7] [8]
The effects of scopolamine were studied for use as a truth serum in interrogations in the early 20th century, [62] but because of the side effects, investigations were dropped. [63] In 2009, the Czechoslovak state security secret police were proven to have used scopolamine at least three times to obtain confessions from alleged antistate ...
Hyoscine butylbromide, also known as scopolamine butylbromide [4] and sold under the brandname Buscopan among others, [5] is an anticholinergic medication used to treat abdominal pain, esophageal spasms, bladder spasms, biliary colic, [6] and renal colic. [7] [8] It is also used to improve excessive respiratory secretions at the end of life. [9]
Scopolamine (Hyoscine) has anti-emetic activity and is, therefore, used to treat motion sickness. Antimuscarinics are also used as anti-parkinsonian drugs. In parkinsonism , there is imbalance between levels of acetylcholine and dopamine in the brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways ...
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
As early as 1960, Sominex was advertised in newspapers as having been hospital-tested. [18] In 1971, Sominex was a combination of scopolamine aminoxide hydrobromide, methapyrilene hydrochloride, and salicylamide, [19] the last of which is noted as a pain killer, [20] and comprised the largest part of the formula. [21]
Early stage of overdose can lead to central nervous system stimulation, for instance, hyperactivity, followed by depression, such as agitation (Anxiety or nervous), delirium, disorientation, hallucinations, seizures, hypertension, or hyperthermia. In late or severe stage of overdose, it could lead to coma, medullary paralysis, death.
Antihistamines may be prescribed in early pregnancy for the treatment of nausea and vomiting along with symptoms of asthma and allergies. [54] First generation antihistamines include diphenhydramine (Benadryl), chlorpheniramine (Diabetic Tussin), hydroxyzine (Atarax), and doxepin (Sinequan). [55]