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Chloral hydrate is a geminal diol with the formula Cl 3 C−CH(OH) 2. It was first used as a sedative and hypnotic in Germany in the 1870s. Over time it was replaced by safer and more effective alternatives but it remained in usage in the United States until at least the 1970s. [ 4 ]
It is given in liquid form, in a solution of sugar syrup and alcohol, containing 9 grams of pentobarbital. This is preceded by an antiemetic to prevent vomiting. [11] It is taken by mouth for physician-assisted death in the United States states of Oregon, Washington, Vermont, and California (as of January 2016).
Clomethiazole is particularly toxic and dangerous if overdosed and is potentially fatal. Alcohol multiplies the effect. As the drug can be fatal in high doses, prescribing clomethiazole for the management of alcohol dependence outside of a controlled environment, for example a hospital, is not recommended, especially because there are much less toxic alternatives, such as diazepam.
Chloral tends to form adducts with water (to give chloral hydrate) and alcohols. Aside from its tendency to hydrate, chloral is notable as a building block in the synthesis of DDT. For this purpose, chloral is treated with chlorobenzene in the presence of a catalytic amount of sulfuric acid: Cl 3 CCHO + 2 C 6 H 5 Cl → Cl 3 CCH(C 6 H 4 Cl) 2 ...
The compound is a preservative, sedative, hypnotic and weak local anesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. [1] Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations.
Human. Secobarbital is used in assisted dying, either euthanasia or palliative sedation. [8] [9] [10]In the Netherlands, individuals have two options for assisted dying: they can orally consume 100 mL of concentrated syrup containing either 15 grams of pentobarbital or 15 grams of secobarbital, or they can choose to have 2 grams of thiopental or 1 gram of propofol administered intravenously by ...
A man on trial for murder claims he killed a woman to protect her daughter from being sexually abused.. Zachary Hughes, a Juilliard-trained pianist, turned himself in to police in South Carolina ...
Chloral betaine [8] [note 1] 2465 Chloral hydrate [8] [note 1] 2744 Chlordiazepoxide [12] 2751 Clobazam [10] 2737 Clonazepam [12] 2768 Clorazepate [12] 2752
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