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Monoamine oxidase inhibitors (also called MAO inhibitors or MAOIs) block the actions of monoamine oxidase enzymes. Monoamine oxidase enzymes are responsible for breaking down neurotransmitters such as dopamine, norepinephrine, and serotonin in the brain.
Various MAO inhibitors have been found to have antidepressant action (e.g., isocarboxazid, iproniazid, phenelzine, tranylcypromine); however, the only MAO inhibitors currently commercially available in the US for use as antidepressant agents are phenelzine and tranylcypromine.
Monoamine oxidase inhibitors (MAOIs) MAOIs block the effects of monoamine oxidase enzymes, and increases levels of dopamine, norepinephrine, and serotonin in the brain. Generic name. Brand name examples. isocarboxazid. Marplan. phenelzine.
SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants.
Monoamine oxidase inhibitors (MAOIs) work by irreversibly blocking the enzyme monoamine oxidase (both MAO-A and MAO-B when used for depression), and preventing the breaking down of neurotransmitters such as serotonin, norepinephrine, and dopamine.
MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Wellbutrin may cause seizures, especially in people with certain medical conditions or when using certain drugs.
Tranylcypromine is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of certain chemicals in the brain. Tranylcypromine is used to treat major depressive episodes in adults when other medicines have not been effective.
Isocarboxazid is a monoamine oxidase inhibitor (MAOI) that works by increasing the levels of certain chemicals in the brain. Isocarboxazid is used to treat symptoms of depression that may include anxiety, panic, or phobias.
SNRI stands for serotonin-norepinephrine reuptake Inhibitor. These may also be called selective serotonin-norepinephrine reuptake Inhibitors (SSNRIs). SNRIs increase levels of serotonin and norepinephrine in the brain by blocking or delaying their reuptake by nerves.
MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. You must wait at least 14 days after stopping an MAO inhibitor before you take fluoxetine.