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It is mainly an anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. Bromazepam typically comes in doses of 3 mg and 6 mg tablets. [4] It was patented in 1961 by Roche and approved for medical use in 1974. [5]
Prazepam is indicated for the short-term treatment of anxiety. After short-term therapy, the dose is usually gradually tapered-off to reduce or avoid any withdrawal or rebound effects. [5] [6] Desmethyldiazepam, an active metabolite, has a very long half-life of 36 to 200 hours, which contributes to the therapeutic effects of prazepam. [7] [8]
Methoxyflurane is used for relief of moderate or severe pain as a result of trauma. [6] [5] It may also be used for short episodes of pain as a result of procedures. [4] Each dose lasts approximately 30 minutes. [12] Pain relief begins after 6–8 breaths and continues for several minutes after stopping inhalation. [13]
Benzodiazepines are not recommended for the treatment of PTSD due to a lack of evidence of benefit and risk of worsening PTSD symptoms. [139] Benzodiazepines are a group of anti-anxiety medications that make people feel calm, relaxed, or sleepy. [140] They are recommended for short-term treatment of severe anxiety, panic, or insomnia.
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Both of them are considered as first-line anti-anxiety medications. TCAs are second-line treatment as they cause more significant adverse effects when compared to the first-line treatment. Benzodiazepines are effective in emergent and short-term treatment of anxiety disorders due to their fast onset but carry the risk of dependence. [4]
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