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Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. [2] This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs , such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small ...
The roles of non-coding RNAs: Ribonucleoproteins are shown in red, non-coding RNAs in blue. A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene.
How NORAD works with PUM proteins to contribute to genomic instability. [1]Noncoding RNA Activated by DNA Damage (NORAD) is a long non-coding RNA that responds to DNA damage and plays a significant role in preserving stability (keeping it accurate and unchanged) of genetic information within cells. [2]
The transcriptome includes the transcripts of protein-coding genes (mRNA plus introns) as well as the transcripts of non-coding genes (functional RNAs plus introns). Ribosomal RNA/rRNA: Usually the most abundant RNA in the transcriptome. Long non-coding RNA/lncRNA: Non-coding RNA transcripts that are more than 200 nucleotides long. Members of ...
non coding RNA - nmRNA non messenger RNA - synonym of ncRNA: sRNA small RNA - synonym of ncRNA: smnRNA small non messenger RNA - synonym of ncRNA: tRNA: transfer RNA RF00005: sRNA soluble RNA - synonym of tRNA: mRNA: messenger RNA - pcRNA protein coding RNA - synonym of mRNA: rRNA: ribosomal RNA multiple families: 5S rRNA: 5S ribosomal RNA ...
For example, long non-coding RNA can directly interact with transcriptional repressors and activators, attenuating or modifying their function. [15] This type of regulation can occur in different ways: the RNA transcript can directly bind to the transcription factor as a co-regulator; also, the RNA can regulate and modify the ability of co ...
Circular ANRIL (cANRIL) is the circular form of ANRIL, a long non-coding RNA (ncRNA). Expression of cANRIL is correlated with risk for atherosclerosis, a disease in which the arteries become hard. It has been proposed that cANRIL can modify INK4/ARF expression, which, in turn, increases risk for atherosclerosis. [40]
A comprehensive compendium of human long non-coding RNAs. [4] [5] lncRNAdb: The Reference Database For Functional Long Noncoding RNAs. [6] LncRNAWiki: A wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs) [7] LncBook