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Lorcaserin, marketed under the brand name Belviq, [4] [5] was a weight-loss drug developed by Arena Pharmaceuticals. It reduces appetite by activating serotonin receptor the 5-HT 2C receptor in the hypothalamus , a region of the brain which is known to control appetite. [ 6 ]
Lorcaserin (Belviq) was FDA approved for weight loss but was withdrawn from the market because a safety clinical trial shows an increased occurrence of cancer. [ 11 ] Cannabinoid receptor antagonists were developed to treat obesity because researchers noticed that cannabinoid agonists (such as THC , the main pharmacologically active component ...
Arena Pharmaceuticals (ARNA) announced, as expected, the U.S. Food and Drug Administration did not approve its weight loss drug Lorcaserin for patients who are obese and overweight because the ...
[3] Aprotinin (Trasylol) 2008 US Increased risk of death. [2] Ardeparin (Normiflo) 2001 US Withdrawn at request of NDA originator, "not for reason of safety or efficacy." [8] [9] Astemizole (Hismanal) 1999 US, Malaysia, Multiple nonspecified markets Fatal arrhythmia [2] [3] Azaribine: 1976 US Thromboembolism. [3] Bendazac: 1993 Spain ...
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The city of Philadelphia settled Monday with the parents of Ellen Greenberg, and the city's medical examiner’s office will take a new look at Greenberg's manner of death.
Pharmacological torture is the use of psychotropic or other drugs to punish or extract information from a person. [1] The aim is to force compliance by causing distress, which could be in the form of pain, anxiety, psychological disturbance, immobilization, or disorientation.
The drug itself reaches its peak plasma level after 1 hour and has also a half-life of 1 hour. Sibutramine is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically active primary and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 16 hours, respectively. Peak plasma concentrations of active ...