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Illustration of chromosome crossover during genetic recombination. In evolutionary genetics, Muller's ratchet (named after Hermann Joseph Muller, by analogy with a ratchet effect) is a process which, in the absence of recombination (especially in an asexual population), results in an accumulation of irreversible deleterious mutations.
This effect is mirrored in humans, where mutations in the WNT4 gene has been observed in MRKH syndrome patients, who display hyperandrogenism. Mutations in WNT4 gene are not always present in individuals with Müllerian anomalies or MRKH syndrome, but the WNT4 gene is the only gene that has been clearly implicated in MRKH.
The condition also occurs in XY males, as they suffer from the effects of low cortisol and salt-wasting, not virilization. Persistent Müllerian duct syndrome – A rare type of pseudohermaphroditism that occurs in 46 XY males, caused by either a mutation in the Müllerian inhibiting substance (MIS) gene, on 19p13, or its type II receptor ...
Cellular compartments in cell biology comprise all of the closed parts within the cytosol of a eukaryotic cell, usually surrounded by a single or double lipid layer membrane. These compartments are often, but not always, defined as membrane-bound organelles. The formation of cellular compartments is called compartmentalization.
The viceroy butterfly (top) appears very similar to the noxious-tasting monarch butterfly (bottom). Although it was for a long time purported to be an example of Batesian mimicry, the viceroy has recently been discovered to be just as unpalatable as the monarch, making this a case of Müllerian mimicry.
Compartment boundaries establish these organizing centers [5] [7] by providing the source of morphogens [9] that are responsible for the positional information required for development and regeneration. [9] [10] The inability of cell competition to occur across the boundary, indicates that each compartment serves as an autonomous unit of growth.
268 11705 Ensembl ENSG00000104899 ENSMUSG00000035262 UniProt P03971 P27106 Q5EC55 RefSeq (mRNA) NM_000479 NM_007445 RefSeq (protein) NP_000470 NP_031471 Location (UCSC) Chr 19: 2.25 – 2.25 Mb Chr 10: 80.64 – 80.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally ...
Müllerian agenesis, also known as Müllerian aplasia, vaginal agenesis, or Mayer–Rokitansky–Küster–Hauser syndrome (MRKH syndrome), is a congenital malformation characterized by a failure of the Müllerian ducts to develop, resulting in a missing uterus and variable degrees of vaginal hypoplasia of its upper portion.