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Epileptogenesis is the gradual process by which a typical brain develops epilepsy. [1] Epilepsy is a chronic condition in which seizures occur. [2] These changes to the brain occasionally cause neurons to fire in an abnormal, hypersynchronous manner, known as a seizure. [3]
Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. [9] The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant number of studies on the subject of kindling ...
Epileptogenesis may occur rapidly, further narrowing this window, but a delayed process known as "secondary epileptogenesis" can influence the progression and severity of epilepsy, offering opportunities for intervention even after its onset. Current research focuses on identifying methods and targets to prevent or slow epilepsy development.
Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy. [1] It is defined as the sudden and unexpected, non-traumatic and non-drowning death of a person with epilepsy, without a toxicological or anatomical cause of death detected during the post-mortem examination.
This process is known as epileptogenesis. [41] There is loss of inhibitory neurons because they die due to the injury. [41] [40] The brain may also adapt and make new neuron connections that may be hyper-excitatory. [41] [40] Brief seizures, such as absence seizures lasting 5–10 seconds, do not cause observable brain damage. [42]
There are many causes of seizures. Organ failure, medication and medication withdrawal, cancer, imbalance of electrolytes, hypertensive encephalopathy , may be some of its potential causes. [ 2 ] The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to ...
A seizure is a paroxysmal episode of symptoms or altered behavior arising from abnormal excessive or synchronous brain neuronal activity. [5] A focal onset seizure arises from a biological neural network within one cerebral hemisphere, while a generalized onset seizure arises from within the cerebral hemispheres rapidly involving both hemispheres.
Ohtahara syndrome (OS), also known as Early Infantile Developmental & Epileptic Encephalopathy (EIDEE) [2] is a progressive epileptic encephalopathy.The syndrome is outwardly characterized by tonic spasms and partial seizures within the first few months of life, [3] and receives its more elaborate name from the pattern of burst activity on an electroencephalogram (EEG).