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Epileptogenesis is the gradual process by which a typical brain develops epilepsy. [1] Epilepsy is a chronic condition in which seizures occur. [2] These changes to the brain occasionally cause neurons to fire in an abnormal, hypersynchronous manner, known as a seizure. [3]
Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. [9] The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant number of studies on the subject of kindling ...
Epileptogenesis may occur rapidly, further narrowing this window, but a delayed process known as "secondary epileptogenesis" can influence the progression and severity of epilepsy, offering opportunities for intervention even after its onset. Current research focuses on identifying methods and targets to prevent or slow epilepsy development.
Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy. [1] It is defined as the sudden and unexpected, non-traumatic and non-drowning death of a person with epilepsy, without a toxicological or anatomical cause of death detected during the post-mortem examination.
This process is known as epileptogenesis. [41] There is loss of inhibitory neurons because they die due to the injury. [41] [40] The brain may also adapt and make new neuron connections that may be hyper-excitatory. [41] [40] Brief seizures, such as absence seizures lasting 5–10 seconds, do not cause observable brain damage. [42]
There are many causes of seizures. Organ failure, medication and medication withdrawal, cancer, imbalance of electrolytes, hypertensive encephalopathy , may be some of its potential causes. [ 2 ] The factors that lead to a seizure are often complex and it may not be possible to determine what causes a particular seizure, what causes it to ...
The degenerative tissue damage caused by human prion diseases (CJD, GSS, and kuru) is characterised by four features: spongiform change (the presence of many small holes), the death of neurons, astrocytosis (abnormal increase in the number of astrocytes due to the destruction of nearby neurons), and amyloid plaque formation.
For those whose seizures are successfully controlled, many of the medications have side effects that cause drowsiness, also impacting driving. As a result, many countries and states place restrictions on driving such as a necessity to be seizure-free for a period of time before being allowed to drive.