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In broad usage, the "practical clinical significance" answers the question, how effective is the intervention or treatment, or how much change does the treatment cause. In terms of testing clinical treatments, practical significance optimally yields quantified information about the importance of a finding, using metrics such as effect size, number needed to treat (NNT), and preventive fraction ...
MCID therefore offers a threshold above which outcome is experienced as relevant by the patient; this avoids the problem of mere statistical significance. Schunemann and Guyatt recommended minimally important difference (MID) to remove the "focus on 'clinical' interpretations" (2005, p. 594).
The term significance does not imply importance here, and the term statistical significance is not the same as research significance, theoretical significance, or practical significance. [1] [2] [18] [19] For example, the term clinical significance refers to the practical importance of a treatment effect. [20]
However, statistical significance is often not enough to define success. To address this issue, the power concept can be extended to the concept of predictive probability of success (PPOS). The success criterion for PPOS is not restricted to statistical significance and is commonly used in clinical trial designs.
Medical statistics (also health statistics) deals with applications of statistics to medicine and the health sciences, including epidemiology, public health, forensic medicine, and clinical research. [1] Medical statistics has been a recognized branch of statistics in the United Kingdom for more than 40 years, but the term has not come into ...
If a clinical endpoint is devastating enough (e.g. death, heart attack), drugs with a high NNT may still be indicated in particular situations. If the endpoint is minor, health insurers may decline to reimburse drugs with a high NNT. NNT is significant to consider when comparing possible side effects of a medication against its benefits.
The rule is useful in the interpretation of clinical trials generally, particularly in phase II and phase III where often there are limitations in duration or statistical power. The rule of three applies well beyond medical research, to any trial done n times. If 300 parachutes are randomly tested and all open successfully, then it is concluded ...
Clinical significance – a conclusion that an intervention has an effect that is of practical meaning to patients Drug discovery – the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy