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The dose should be increased after a minimum of 3 days up to approximately 1.2 mg/kg daily (target dose) as a single or two divided doses (in the morning and late afternoon). For children older than 6 years old, over 70 kg, acute treatment should be started with 40 mg/day orally and increased up to 80 mg/day after a minimum of 3 days.
[10] [25] Medications for depression affect the transmission of serotonin, norepinephrine, and dopamine. [10] Older and less selective antidepressants like TCAs and MAOIs inhibit the reuptake or metabolism of norepinephrine and serotonin in the brain, which results in higher concentrations of neurotransmitters. [25]
[1] [2] [23] [25] These drugs also release dopamine to a much lesser extent however (e.g., ~10- to 20-fold less potently). [1] [2] [23] [25] No highly selective NRAs are currently known. [26] Among the most selective known NRAs is ephedrine, which had about 19-fold higher potency for inducing norepinephrine release over dopamine release in one ...
Ginkgo biloba extract (EGb761) — "The norepinephrine (NET), the serotonin (SERT), the dopamine (DAT) uptake transporters and MAO activity are inhibited by EGb761 in vitro" [157] St John's Wort — natural product and over-the-counter herbal antidepressant Hyperforin; Adhyperforin; Uliginosin B — IC 50 DA = 90 nM, 5-HT = 252 nM, NE = 280 nM ...
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]
Approximately 90% of a dose of phenylpropanolamine is excreted in the urine unchanged within 24 hours. [4] [6] [7] [5] About 4% of excreted material is in the form of metabolites. [4] The elimination half-life of immediate-release phenylpropanolamine is about 4 hours, with a range in different studies of 3.7 to 4.9 hours.
Having ED is a common problem that both older men and younger men in the United States experience. In fact, some research indicates that 30 million American men experience symptoms of ED — and ...
[97] [90] [214] [84] [85] Differences in effectiveness between different antidepressants are small and not clinically meaningful. [215] [214] The small advantage of antidepressants over placebo is often statistically significant and is the basis for their regulatory approval, but is sufficiently modest that its clinical significance is doubtful.