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Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. [7]
Celebrex (and other brand names for celecoxib) was introduced in 1999 and rapidly became the most frequently prescribed new drug in the United States. By October 2000, its US sales exceeded 100 million prescriptions per year for $3 billion, and was still rising. Sales of Celebrex alone reached $3.1 billion in 2001.
[1] [11] Celecoxib and parecoxib have a sulfonamide substituent (SO 2 NH 2) in para-position on one of the aryl rings while etoricoxib and rofecoxib have a methylsulfone (SO 2 CH 3). [12] The oxidation state on the sulfur is important for selectivity; sulfones and sulfonamides are selective for COX-2 but sulfoxides and sulfides are not.
Cost: $7 | Active ingredients: Lidocaine | Type: Cream | Amount: 4.3 ounces. Lidocaine is another popular ingredient found in pain relief creams. It's a topical anesthetic that's often used to ...
US Dermatologic toxicity. [3] Brotizolam: 1989 UK Animal carcinogenicity. [3] Bromfenac: 1998 US Severe hepatitis and liver failure (requiring transplantation). [2] Bucetin: 1986 Germany Kidney damage [3] Buformin: 1978 Germany Metabolic toxicity. [3] Bunamiodyl: 1963 Canada, UK, US Nephropathy. [11] Butamben (Efocaine)(Butoforme) 1964 US
Tonka Beans. This wrinkly legume from South America underwent a recent boom in the fine-dining world due to its notes of vanilla, almond, and cinnamon, but it has actually been illegal in the U.S ...
The ban gave Chinese-owned ByteDance until 19 January to sell TikTok. If it fails to do so, a nationwide ban is set to come into force – despite having 170 million US users.
US yearly overdose deaths, and the drugs involved. There were around 110,500 drug overdose deaths overall in 2022 in the US. [36] 2010: The Fiscal Year 2011 National Drug Control Budget proposed by the Obama administration devoted significant new resources, $340 million, to the prevention and treatment of drug abuse. [37]