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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. [1] [2] It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS.
Lab disk for protein structure analysis via small-angle X-ray scattering. The centrifugal micro-fluidic biochip or centrifugal micro-fluidic biodisk is a type of lab-on-a-chip technology, also known as lab-on-a-disc, that can be used to integrate processes such as separating, mixing, reaction and detecting molecules of nano-size in a single piece of platform, including a compact disk or DVD.
Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1] LoCs represent the most promising alternative to replace animal testing.
3D Sarfus image of a DNA biochip. The microarray—the dense, two-dimensional grid of biosensors—is the critical component of a biochip platform. Typically, the sensors are deposited on a flat substrate, which may either be passive (e.g. silicon or glass) or active, the latter consisting of integrated electronics or micromechanical devices that perform or assist signal transduction.
Microfluidic techniques such as droplet microfluidics, paper microfluidics, and lab-on-a-chip are used in the realm of food science in a variety of categories. [131] Research in nutrition, [132] [133] food processing, and food safety benefit from microfluidic technique because experiments can be done with less reagents. [131]
The advantages of PCR chips include shorter thermal-cycling time, more uniform temperature which enhances yield, and portability for point-of-care applications. [39] Two challenges in microfluidic PCR chips are PCR inhibition and contamination due to the large surface-to-volume ratio increasing surface-reagent interactions. [39]
US & Canada, Jan. 24, 2025 (GLOBE NEWSWIRE) -- According to a comprehensive report from The Insight Partners, “Microelectrode Array in Vitro Market Size and Forecast (2021–2031), Global and Regional Growth Opportunity Analysis” The microelectrode array in vitro market is expected to reach US$ 25.67 million by 2031 from US$ 17.95 million in 2023; it is projected to record a CAGR of 4.6% ...
The Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) has worked with scientists, since 1981, to find new methods to replace the use of laboratory animals in experiments, reduce the number of animals tested, and refine necessary tests to eliminate pain and distress (the Three Rs as described in Russell and Burch's Principles of Humane Experimental Technique). [1]
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