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Benzotrichloride (BTC), also known as α,α,α-trichlorotoluene, phenyl chloroform or (trichloromethyl)benzene, is an organic compound with the formula C 6 H 5 CCl 3. Benzotrichloride is an unstable, colorless or somewhat yellowish, viscous, chlorinated hydrocarbon with a penetrating odor.
For small-scale laboratory preparations, trifluorotoluene is synthesized by coupling an aromatic halide and trifluoromethyl iodide in the presence of a copper catalyst: [2] PhX + CF 3 I → PhCF 3 (where X = I, Br) Industrial production is done by reacting benzotrichloride with hydrogen fluoride in a pressurized reactor. [3] PhCCl 3 + 3 HF → ...
[3] [4] The centre is accredited by the National Accreditation Board for Testing and Calibration Laboratories [3] [5] as part of the overall clinical laboratory services of Amrita Hospital. [ 1 ] It is listed as a public facility and operates 24 hours a day in the World Health Organization's directory of poison control centres.
U.S. Army Public Health Center Toxicology Lab technician assessing samples. Toxicology testing, also known as safety assessment, or toxicity testing, is the process of determining the degree to which a substance of interest negatively impacts the normal biological functions of an organism, given a certain exposure duration, route of exposure, and substance concentration.
Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster 478: Rodent Dominant Lethal Test 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay 482
C 6 H 5 CH 3 + Cl 2 → C 6 H 5 CH 2 Cl + HCl. In this way, approximately 100,000 tonnes are produced annually. The reaction proceeds by the free radical process, involving the intermediacy of free chlorine atoms. [4] Side products of the reaction include benzal chloride and benzotrichloride.
The CompTox Chemicals Dashboard is a freely accessible online database created and maintained by the U.S. Environmental Protection Agency (EPA). The database provides access to multiple types of data including physicochemical properties, environmental fate and transport, exposure, usage, in vivo toxicity, and in vitro bioassay.
Benzal chloride is produced by the free radical chlorination of toluene, being preceded in the process by benzyl chloride (C 6 H 5 CH 2 Cl) and followed by benzotrichloride (C 6 H 5 CCl 3): C 6 H 5 CH 3 + Cl 2 → C 6 H 5 CH 2 Cl + HCl C 6 H 5 CH 2 Cl + Cl 2 → C 6 H 5 CHCl 2 + HCl C 6 H 5 CHCl 2 + Cl 2 → C 6 H 5 CCl 3 + HCl