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Endochondral ossification is responsible for development of most bones including long and short bones, [4] the bones of the axial (ribs and vertebrae) and the appendicular skeleton (e.g. upper and lower limbs), [5] the bones of the skull base (including the ethmoid and sphenoid bones) [6] and the medial end of the clavicle. [7]
Diagram showing stages of endochondral ossification. Endochondral ossification is the formation of long bones and other bones. This requires a hyaline cartilage precursor. There are two centers of ossification for endochondral ossification. The primary center. In long bones, bone tissue first appears in the diaphysis (middle of shaft).
The skull is a complex structure; its bones are formed both by intramembranous and endochondral ossification. The skull roof bones, comprising the bones of the facial skeleton and the sides and roof of the neurocranium, are dermal bones formed by intramembranous ossification, though the temporal bones are formed by endochondral ossification.
Endochondral ossification occurs in long bones and most other bones in the body; it involves the development of bone from cartilage. This process includes the development of a cartilage model, its growth and development, development of the primary and secondary ossification centers , and the formation of articular cartilage and the epiphyseal ...
The ribs begin as cartilage that later ossifies – a process called endochondral ossification. Primary ossification centers are located near the angle of each rib, and ossification continues in the direction away from the head and neck. During adolescence secondary ossification centers are formed in the tubercles and heads of the ribs. [8]
Definition Etymologic memory aid; apophysis: Any of various processes or protuberances on a bone. apo-+ physis, "outward from the growth part; outgrowth" diaphysis: The long, relatively straight main body of a long bone; region of primary ossification. Also known as the shaft. dia-+ physis, "between the growth parts" epiphysis
The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. Bone growth in length is stimulated by the production of growth hormone (GH), a secretion of the anterior lobe of the pituitary gland.
In human anatomy, the neurocranium, also known as the braincase, brainpan, brain-pan, [1] [2] or brainbox, is the upper and back part of the skull, which forms a protective case around the brain. [3] In the human skull, the neurocranium includes the calvaria or skullcap. The remainder of the skull is the facial skeleton.