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The Mantoux test or Mendel–Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for screening for tuberculosis (TB) and for tuberculosis diagnosis.
p-Phenylenediamine (PPD) is an organic compound with the formula C 6 H 4 (NH 2) 2. This derivative of aniline is a white solid, but samples can darken due to air oxidation. [ 1 ] It is mainly used as a component of engineering polymers and composites like kevlar .
Allergic reactions may occasionally occur. [1] The test may be falsely positive in those who have been previously vaccinated with BCG or have been infected by other types of mycobacteria. [2] The test may be falsely negative within ten weeks of infection, in those less than six months old, and in those who have been infected for many years. [2]
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If all doubtful indications are instead classified as positive, there is no significant difference between the OT test, the PPD tine test, or the Mantoux test. [3] Furthermore, the tine test is faster and easier to administer than the Mantoux test and has been recommended for screening children. [9] [10]
The treatment of immediate hypersensitivity reactions includes the management of anaphylaxis with intramuscular adrenaline (epinephrine), oxygen, intravenous (IV) antihistamine, support blood pressure with IV fluids, avoid latex gloves and equipment in patients who are allergic, and surgical procedures such as tracheotomy if there is severe ...
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