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Examples of periosteal reactive bone in selected specimens of Triceratops. A periosteal reaction can result from a large number of causes, including injury and chronic irritation due to a medical condition such as hypertrophic osteopathy, bone healing in response to fracture, chronic stress injuries, subperiosteal hematomas, osteomyelitis, and cancer of the bone.
The advancing tumour displaces the periosteum away from the bone medulla. The displaced and now lateral periosteum attempts to regenerate underlying bone. This describes a periosteal reaction. [citation needed] The main causes for this sign are osteosarcoma, Ewing's sarcoma, eumycetoma, and a subperiosteal abscess. [3] [4]
It is called onion skin periosteal reaction because it resembles the layers of an onion. These layers are formed due to any pathological process that leads to the variable, excessive growth of the bone. [1] Onion skin periosteal reaction is seen in osteosarcoma, [2] Ewing sarcoma and Langerhans cell histiocytosis. [3]
The periosteum is a membrane that covers the outer surface of all bones, [1] except at the articular surfaces (i.e. the parts within a joint space) of long bones. (At the joints of long bones the bone's outer surface is lined with "articular cartilage", a type of hyaline cartilage.)
The outer surface of a bone is lined by a thin layer of connective tissue that is very similar in morphology and function to endosteum. It is called the periosteum , or the periosteal surface. During bone growth , the width of the bone increases as osteoblasts lay new bone tissue at the periosteum.
Sunburst periosteal reaction; Superior triangle sign; Swan neck deformity; Swiss cheese appearance (cardiac) T. Talar beak; Target calcification;
The periosteal cells distal to (at the far end of) the fracture gap develop into osteoblasts, which form woven bone [citation needed] through bone resorption of calcified cartilage and recruitment of bone cells and osteoclasts. [4] The fibroblasts within the granulation tissue develop into chondroblasts which also form hyaline cartilage.
Bone tissue is removed by osteoclasts, and then new bone tissue is formed by osteoblasts. Both processes utilize cytokine (TGF-β, IGF) signalling.In osteology, bone remodeling or bone metabolism is a lifelong process where mature bone tissue is removed from the skeleton (a process called bone resorption) and new bone tissue is formed (a process called ossification or new bone formation).