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A box model explaining the processes of toxicokinetics and toxicodynamics. While toxicokinetics describes the changes in the concentrations of a toxicant over time due to the uptake, biotransformation, distribution and elimination of toxicants, toxicodynamics involves the interactions of a toxicant with a biological target and the functional or structural alterations in a cell that can ...
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity.It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
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Downloaded received mixed reviews from movie critics upon its release. At Metacritic , which assigns a weighted average rating out of 100 to reviews from mainstream critics, the film has received an average score of 56, based on 6 reviews, indicating "mixed or average" feedback. [ 13 ]
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