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Cerebellar granule cells form the thick granular layer of the cerebellar cortex and are among the smallest neurons in the brain. (The term granule cell is used for several unrelated types of small neurons in various parts of the brain.) Cerebellar granule cells are also the most numerous neurons in the brain: in humans, estimates of their total ...
The cerebellar granule cells also play a role in orchestrating the tonic conductances which control sleep in conjunction with the ambient levels of GABA which are found in the brain. Dentate granule cells. Loss of dentate gyrus neurons from the hippocampus results in spatial memory deficits.
Cerebellar granule cells, in contrast to Purkinje cells, are among the smallest neurons in the brain. They are also the most numerous neurons in the brain: In humans, estimates of their total number average around 50 billion, which means that about 3/4 of the brain's neurons are cerebellar granule cells. [11]
The cerebellum, or "little brain," is a portion of the brain attached to the brainstem at the pons. Among other functions, it is important for balance, coordinating movement, and maintaining muscle tone. [5] The outer layer of the cerebellum, the cortex, is made up of three layers containing two classes of neurons.
Because of its large number of tiny granule cells, the cerebellum contains more neurons than the rest of the brain put together, but it only takes up 10% of total brain volume. [3] The cerebellum receives nearly 200 million input fibers; in contrast, the optic nerve is composed of a mere one million fibers.
They develop in the cerebellar primordium that covers the fourth ventricle and below a fissure-like region called the isthmus of the developing brain. Purkinje cells migrate toward the outer surface of the cerebellar cortex and form the Purkinje cell layer. Purkinje cells are born during the earliest stages of cerebellar neurogenesis.
Stellate cells are neurons in the central nervous system, named for their star-like shape formed by dendritic processes radiating from the cell body. These cells play significant roles in various brain functions, including inhibition in the cerebellum and excitation in the cortex, and are involved in synaptic plasticity and neurovascular coupling.
The NeuN/Fox-3 antibody binds to the small cerebellum granule cell neurons, which form a prominent layer. In contrast antibody to the close relative of NeuN/Fox-3, Fox-2, is shown in red. Fox-2 antibody stains Purkinje neurons and Golgi cell which are not recognized by the NeuN/Fox-3 antibody. The Purkinje cells form a layer above the much more ...