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Among other functions, it is important for balance, coordinating movement, and maintaining muscle tone. [5] The outer layer of the cerebellum, the cortex, is made up of three layers containing two classes of neurons. One of these classes has been identified as granule cells, which are produced by the rhombic lip. [6]
The granule cells, produced by the rhombic lip, are found in the granule cell layer of the cerebellar cortex. They are small and numerous. They are small and numerous. They are characterized by a very small soma and several short dendrites which terminate with claw-shaped endings.
UBCs function to amplify inputs from the vestibular ganglia and nuclei by spreading and prolonging excitation within the granular layer. [ 2 ] [ 7 ] They receive glutamatergic inputs on its dendritic brush from a single mossy fibre terminal in the form of a giant glutamatergic synapse and make glutamatergic synapses with granule cells and other ...
These cells are the primary output neurons of the cerebellar cortex and cerebellum. The second germinal zone (cellular birthplace) is known as the rhombic lip, neurons then move by human embryonic week 27 to the external granular layer. This layer of cells—found on the exterior of the cerebellum—produces the granule neurons.
The cerebellum also develops from the alar plate, particularly from the rhombic lip. This is considered an exception to the general differentiation scheme from the alar plate, as the alar plate generally gives rise to sensory derivatives. [1]
Hindbrain rhombic lip is composed of discrete progenitor cell populations allocated by Pax6. Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki SM. Neuron 2005-12-22 [25] Origin of the precerebellar system. Rodriguez CI, Dymecki SM. Neuron 2000-09-01 [25]
From ancient history to the modern day, the clitoris has been discredited, dismissed and deleted -- and women's pleasure has often been left out of the conversation entirely. Now, an underground art movement led by artist Sophia Wallace is emerging across the globe to challenge the lies, question the myths and rewrite the rules around sex and the female body.
Although medulloblastomas are thought to originate from immature or embryonal cells at their earliest stage of development, the cell of origin depends on the subgroup of medulloblastoma. WNT tumors originate from the lower rhombic lip of the brainstem, while SHH tumors originate from the external granular layer. [8]