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Since absolute aggregation rates are difficult to measure, one often refers to the dimensionless stability ratio W, defined as = where k fast is the aggregation rate coefficient in the fast regime, and k the coefficient at the conditions of interest. The stability ratio is close to unity in the fast regime, increases in the slow regime, and ...
In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. [1] [2] Protein aggregates have been implicated in a wide variety of diseases known as amyloidoses, including ALS, Alzheimer's, Parkinson's and prion ...
Flocculation (except in polymer science) Process of contact and adhesion whereby dispersed molecules or particles are held together by weak physical interactions ultimately leading to phase separation by the formation of precipitates of larger than colloidal size.
Self-assembled nano-structure is an object that appears as a result of ordering and aggregation of individual nano-scale objects guided by some physical principle. A particularly counter-intuitive example of a physical principle that can drive self-assembly is entropy maximization.
In general, amyloid polymerization (aggregation or non-covalent polymerization) is sequence-sensitive, that is mutations in the sequence can induce or prevent self-assembly. [ 61 ] [ 62 ] For example, humans produce amylin , an amyloidogenic peptide associated with type II diabetes, but in rats and mice prolines are substituted in critical ...
The accumulation of platelets to the site of a wound to form a platelet plug or a thrombus; Flocculation, a process where a solute comes out of solution in the form of floccules or flakes; Overdispersion or statistical aggregation, where the variance of a distribution is higher than which we expect. Aggregation pheromone
In materials science, segregation is the enrichment of atoms, ions, or molecules at a microscopic region in a materials system. While the terms segregation and adsorption are essentially synonymous, in practice, segregation is often used to describe the partitioning of molecular constituents to defects from solid solutions, [1] whereas adsorption is generally used to describe such partitioning ...
The aggregation number of micelles can be determined by isothermal titration calorimetry when the aggregation number is not too high. [2] [3] Another classical experiment to determine the mean aggregation number would involve the use of a luminescent probe, a quencher and a known concentration of surfactant. If the concentration of the quencher ...