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Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.
Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. [44] About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. [44] The terminal elimination half-lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively. [44]
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GoldenEye: Source - A total conversion for Half-Life 2 that aims to recreate the original Nintendo 64 classic GoldenEye 007. It received Mod DB's "Editors' Choice for Reinvention" in 2006, [53] "Third Place, Mod of the Year" in 2006, [34] and "Fourth Place, Top Unreleased Mods" in 2005. [54] Half-Life 2: Capture the Flag - A simple capture-the ...
Clinical trials for valsartan treatment for hypertension versus placebo demonstrate side effects like viral infection (3% vs 2%), fatigue (2% vs 1%) and abdominal pain (2% vs 1%). Minor side effects that occurred at >1% but were similar to rates from the placebo group include: [7] headache; dizziness; upper respiratory infection; cough; diarrhea
Half-Life 2: 2012 September 14 2020 March 6 The game is a remake of Valve's game Half-Life. Chex Quest: Doom: 1996 A total conversion of The Ultimate Doom, Chex Quest was a Chex cereal promotion aimed at children aged 6–9 and up. [10] [11] It was the first video game ever to be included in cereal boxes as a prize. [12] Chivalry: Medieval ...
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Valsartan has an oral bioavailability of approximately 25% and reaches peak blood concentrations around 2–4 hours after ingestion. [2] [13] The estimated elimination half-life is determined to be approximately 6 hours, volume distribution of 17 litres, and a protein binding of 95% is seen.