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Toripalimab (Loqtorzi) is a humanized IgG4 monoclonal antibody against PD-1 approved in China in 2018 and in the United States in 2023. [18] [19] [20] Tislelizumab (Tevimbra) is a humanized IgG4 anti–PD-1 monoclonal antibody approved in China in 2019 and in the United States in 2024 for certain gastrointestinal cancers.
This list of over 500 monoclonal antibodies includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage. See the list of FDA-approved therapeutic monoclonal antibodies in the monoclonal antibody therapy page.
Nivolumab is approved to treat melanoma, lung cancer, kidney cancer, bladder cancer, head and neck cancer, and Hodgkin's lymphoma. [16] Pembrolizumab (brand name Keytruda) is another PD-1 inhibitor that was approved by the FDA in 2014 and was the second checkpoint inhibitor approved in the United States. [17] Keytruda is approved to treat ...
Bristol-Myers might finish second in the race to win approval for a PD-1 drug, but it definitely has the most clinical data. The recently released, long-term survival figures that has the research ...
Like other PD-1 drugs such as Merck's Keytruda, it was previously available through infusions and patients received it via an intravenous drip in a health office. FDA approves injectable version ...
As of 2015, the only PD-1/PD-L1 targeting drugs on the market are pembrolizumab and nivolumab. [59] By April 2016, Merck applied for approval to market the drug in Japan and signed an agreement with Taiho Pharmaceutical to co-promote it there. [60] In July 2015, pembrolizumab received marketing approval in the European Union. [19] [61] [13]
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