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HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity. [1]HMG-box domains are found in some high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin. [3]
The SRY gene on the Y Chromosome, responsible for male sexual differentiation, contains an HMG-Box domain. A member of the HMG family of proteins, HMGB1, has also been shown to have an extracellular activity as a chemokine, attracting neutrophils and mononuclear inflammatory cells to the infected liver. [3]
SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues ...
High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene. [ 3 ] [ 4 ] HMG-1 belongs to the high mobility group and contains a HMG-box domain.
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has a critical role in maintenance of embryonic and neural stem cells .
HMG-box domains are found in high mobility group proteins which are involved in a variety of DNA-dependent processes like replication and transcription. They also alter the flexibility of the DNA by inducing bends.
A new HGTV designer is taking the reins on Love It or List It!. Following longtime co-host Hilary Farr's announcement that she was leaving the show in 2023 after 19 seasons, the long-running HGTV ...
HMG-box containing 4 is a protein that in humans is encoded by the HMGXB4 gene. [5] Function. High mobility group (HMG) proteins are nonhistone chromosomal proteins ...