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Apocrine-like cells form in a lining of developing microcysts, due to the pressure buildup within the lumen. The pressure build up is caused by secretions. [ 5 ] This type of metaplasia represents an exception to the common rule of metaplasia increasing the risk for developing cancer in that apocrine metaplasia doesn't increase the possibility ...
Micrograph showing apocrine metaplasia of the breast with typical features [3] H&E stain. Barrett's esophagus is an abnormal change in the cells of the lower esophagus, thought to be caused by damage from chronic stomach acid exposure. The following table lists some common tissues susceptible to metaplasia, and the stimuli that can cause the ...
The World Health Organization (2019) did not define any of the other invasive apocrine carcinomas as diagnostically distinct entities, [8] but did recognize invasive ductal breast carcinoma in which >90% of its cancer cells were apocrine gland cells as "carcinoma with apocrine differentiation."
Diagnosis involves ruling out breast cancer. [1] Fibrocystic changes include fibroadenomas, fibrosis, papillomas of the breast, [1] and apocrine-type metaplasia. [4] Management may involve education about the condition, using a well fitting bra, and pain medication, if needed. [1] Occasionally danazol or tamoxifen may be used for pain. [1]
These classifications are spindle cell, squamous cells, matrix-producing, carcinosarcoma, and MBC with osteoclastic giant cell. Another research group, Oberman et al., proposed a classification system consisting of spindle cell carcinoma, invasive ductal carcinoma with extensive squamous metaplasia, and invasive ductal carcinoma with ...
Micrograph showing apocrine-type metaplasia of the breast with typical oncocytes. [2] H&E stain. Oncocytes (left of image), as seen in a renal oncocytoma. H&E stain. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytes can be benign or malignant.
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