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Lipids are a broad group of organic compounds which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes.
Lipids are a class of relatively water-insoluble organic molecules, which are the "basic" components of biological membranes. There are three forms of lipids: phospholipids , steroids , and triglycerides .
LIPID MAPS was founded in 2003 with NIH funding. [14] LIPID MAPS was previously funded by a multi-institutional grant from Wellcome, and is now funded under an MRC Partnership award, held jointly by University of Cardiff led by Prof Valerie O'Donnell, the Babraham Institute, UCSD and Swansea University, and The University of Edinburgh.
There are two major classes of membrane lipids: glycerophospholipids and sphingolipids. Although many different membrane lipids are synthesized in our body, pathways share the same pattern. The first step is synthesizing the backbone (sphingosine or glycerol), the second step is the addition of fatty acids to the backbone to make phosphatidic acid.
Membrane lipids are a group of compounds (structurally similar to fats and oils) which form the lipid bilayer of the cell membrane. The three major classes of membrane lipids are phospholipids, glycolipids, and cholesterol. Lipids are amphiphilic: they have one end that is soluble in water ('polar') and an ending that is soluble in fat ...
Fatty acids are a major component of the lipids (up to 70% by weight) in some species such as microalgae [2] but in some other organisms are not found in their standalone form, but instead exist as three main classes of esters: triglycerides, phospholipids, and cholesteryl esters.
These lipids belong to a heterogeneous class of predominantly nonpolar compounds, mostly insoluble in water, but soluble in nonpolar organic solvents such as chloroform and benzene. [ 1 ] "Simple lipid" can refer to many different types of lipid depending on the classification system used, but the most basic definitions usually classify simple ...
Since lipids have a variety of functions in the body, being able to understand which specific types are present in the body and at what levels is crucial to understand the diseases that result due to lipids. [14] Methods of lipidomic analysis include mass spectrometry and chromatography. [6]