Search results
Results From The WOW.Com Content Network
Recombination frequency is a measure of genetic linkage and is used in the creation of a genetic linkage map. Recombination frequency (θ) is the frequency with which a single chromosomal crossover will take place between two genes during meiosis. A centimorgan (cM) is a unit that describes a recombination frequency of 1%. In this way we can ...
The linkage disequilibrium reflects both changes in the intensity of the linkage correlation and changes in gene frequency. This poses an issue when comparing linkage disequilibrium between alleles with differing frequencies. Normalization of linkage disequilibrium allows these alleles to be compared more easily.
In genetic engineering, recombination can also refer to artificial and deliberate recombination of disparate pieces of DNA, often from different organisms, creating what is called recombinant DNA. A prime example of such a use of genetic recombination is gene targeting , which can be used to add, delete or otherwise change an organism's genes.
Meiotic recombination allows a more independent segregation between the two alleles that occupy the positions of single genes, as recombination shuffles the allele content between homologous chromosomes. [citation needed] Recombination results in a new arrangement of maternal and paternal alleles on the same chromosome.
The distance between two alleles on a chromosome can be determined by calculating the percentage or recombination between two loci. These probabilities of recombination can be used to construct a linkage map, or a graphical representation of the location of genes and gene in respect to one another. If linkage is complete, there should be no ...
There are 23 + 152 + 148 + 27 = 350 progeny showing recombination between genes A and B. And there are 81 + 23 + 27 + 89 = 220 progeny showing recombination between genes B and C. Thus the expected rate of double recombination is (350 / 1000) * (220 / 1000) = 0.077, or 77 per 1000. However, there are actually only 23 + 27 = 50 double recombinants.
Within a family, linkage occurs when two genetic markers (points on a chromosome) remain linked on a chromosome rather than being broken apart by recombination events during meiosis, shown as red lines. In a population, contiguous stretches of founder chromosomes from the initial generation are sequentially reduced in size by recombination events.
[Note: This effect is often erroneously equated with "clonal interference", which happens when A and B mutations arise in different wild type (ab) individuals and describes the ensuing competition between Ab and aB lineages.] [2] There tends to be a correlation between the rate of recombination and the likelihood of the preferred haplotype (in ...