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Cruciform DNA is a form of non-B DNA, or an alternative DNA structure. The formation of cruciform DNA requires the presence of palindromes called inverted repeat sequences. [ 1 ] These inverted repeats contain a sequence of DNA in one strand that is repeated in the opposite direction on the other strand.
Glycol nucleic acid (left) is an example of a xeno nucleic acid because it has a different backbone than DNA (right). Xenonucleic acids (XNA) are synthetic nucleic acid analogues that are made up of non-natural components such as alternative nucleosides, sugars, or backbones. [1] [2] Xenonucleic acids have different properties to endogenous ...
A-DNA, is a form of the DNA duplex observed under dehydrating conditions. It is shorter and wider than B-DNA. RNA adopts this double helical form, and RNA-DNA duplexes are mostly A-form, but B-form RNA-DNA duplexes have been observed. [14] In localized single strand dinucleotide contexts, RNA can also adopt the B-form without pairing to DNA. [15]
Nucleic acid design can be used to create nucleic acid complexes with complicated secondary structures such as this four-arm junction. These four strands associate into this structure because it maximizes the number of correct base pairs, with A's matched to T's and C's matched to G's.
Common changes in nucleotide analogues. Nucleic acid analogues are used in molecular biology for several purposes: Investigation of possible scenarios of the origin of life: By testing different analogs, researchers try to answer the question of whether life's use of DNA and RNA was selected over time due to its advantages, or if they were chosen by arbitrary chance; [3]
False-color Cassini radar mosaic of Titan's north polar region; the blue areas are lakes of liquid hydrocarbons. "The existence of lakes of liquid hydrocarbons on Titan opens up the possibility for solvents and energy sources that are alternatives to those in our biosphere and that might support novel life forms altogether different from those on Earth."—NASA Astrobiology Roadmap 2008 [1]
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Three DNA conformations are believed to be found in nature, A-DNA, B-DNA, and Z-DNA. The "B" form described by James D. Watson and Francis Crick is believed to predominate in cells. [ 2 ] James D. Watson and Francis Crick described this structure as a double helix with a radius of 10 Å and pitch of 34 Å , making one complete turn about its ...