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In other words, the ratio of the EC50s of the inhibited and un-inhibited curves. Thus, r represents both the strength of an antagonist and the concentration of the antagonist that was applied. An equation derived from the Gaddum equation can be used to relate r to [], as follows: = + [] where r is the dose ratio
The therapeutic ratio in radiotherapy for cancer treatment is determined by the maximum radiation dose for killing cancer cells and the minimum radiation dose causing acute or late morbidity in cells of normal tissues. [13] Both of these parameters have sigmoidal dose–response curves. Thus, a favorable outcome in dose–response for tumor ...
Tissue-air ratio is defined as the ratio of the dose to water at a given depth to the dose in air measured with a buildup cap: = (,) (,) where D(f,z) is the dose at a given depth z and distance focus-detector f; and D(f,0) is the dose in air (z=0).
The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.
In other words, it is the ratio of amount of drug in a body (dose) to concentration of the drug that is measured in blood, plasma, and un-bound in interstitial fluid. [3] [4] The V D of a drug represents the degree to which a drug is distributed in body tissue rather than the plasma.
The relative biological effectiveness for radiation of type R on a tissue is defined as the ratio = where D X is a reference absorbed dose of radiation of a standard type X, and D R is the absorbed dose of radiation of type R that causes the same amount of
The c inj value is calculated as ratio of two independent measurements: the injected radioactivity (injected dose, ID) and the body weight (BW) of the subject. The ID can be estimated e.g. as difference in the radioactivity of the syringe before and after injection, if deemed necessary with correction for physical decay between each of those measurements and the time of injection.
A dose–response curve is a coordinate graph relating the magnitude of a dose (stimulus) to the response of a biological system. A number of effects (or endpoints) can be studied. The applied dose is generally plotted on the X axis and the response is plotted on the Y axis. In some cases, it is the logarithm of the dose that is plotted on the ...