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  2. Hydrophilic-lipophilic balance - Wikipedia

    en.wikipedia.org/wiki/Hydrophilic-lipophilic_balance

    HLB scale showing classification of surfactant function. The hydrophilic–lipophilic balance (HLB) of a surfactant is a measure of its degree of hydrophilicity or lipophilicity, determined by calculating percentages of molecular weights for the hydrophilic and lipophilic portions of the surfactant molecule, as described by Griffin in 1949 [1] [2] and 1954. [3]

  3. Octanol-water partition coefficient - Wikipedia

    en.wikipedia.org/wiki/Octanol-water_partition...

    It is also called n-octanol-water partition ratio. [2] [3] [4] K ow serves as a measure of the relationship between lipophilicity (fat solubility) and hydrophilicity (water solubility) of a substance. The value is greater than one if a substance is more soluble in fat-like solvents such as n-octanol, and less than one if it is more soluble in ...

  4. Lipophilic efficiency - Wikipedia

    en.wikipedia.org/wiki/Lipophilic_efficiency

    Lipophilic efficiency. Lipophilic efficiency[1] (LiPE), sometimes referred to as ligand-lipophilicity efficiency (LLE) is a parameter used in drug design and drug discovery to evaluate the quality of research compounds, linking potency and lipophilicity in an attempt to estimate druglikeness. [2][3] For a given compound LiPE is defined as the ...

  5. Partition coefficient - Wikipedia

    en.wikipedia.org/wiki/Partition_coefficient

    Partition coefficient. In the physical sciences, a partition coefficient (P) or distribution coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio is therefore a comparison of the solubilities of the solute in these two liquids. The partition coefficient generally refers ...

  6. Lipid bilayer mechanics - Wikipedia

    en.wikipedia.org/wiki/Lipid_bilayer_mechanics

    Lipid bilayer mechanics is the study of the physical material properties of lipid bilayers, classifying bilayer behavior with stress and strain rather than biochemical interactions. Local point deformations such as membrane protein interactions are typically modelled with the complex theory of biological liquid crystals but the mechanical ...

  7. Dissociation constant - Wikipedia

    en.wikipedia.org/wiki/Dissociation_constant

    Dissociation constant. In chemistry, biochemistry, and pharmacology, a dissociation constant (KD) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its ...

  8. Lipid bilayer - Wikipedia

    en.wikipedia.org/wiki/Lipid_bilayer

    Lipid bilayer. This fluid lipid bilayer cross section is made up entirely of phosphatidylcholine. The three main structures phospholipids form in solution; the liposome (a closed bilayer), the micelle and the bilayer. The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules.

  9. High-density lipoprotein - Wikipedia

    en.wikipedia.org/wiki/High-density_lipoprotein

    High-density lipoprotein (HDL) is one of the five major groups of lipoproteins. [ 1 ] Lipoproteins are complex particles composed of multiple proteins which transport all fat molecules (lipids) around the body within the water outside cells. They are typically composed of 80–100 proteins per particle (organized by one, two or three ApoA).